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Fig. 6 | Journal of Experimental & Clinical Cancer Research

Fig. 6

From: Targeted inhibition of PDGFRA with avapritinib, markedly enhances lenvatinib efficacy in hepatocellular carcinoma in vitro and in vivo: clinical implications

Fig. 6

Correlation between PDGFRA Expression Levels and Response to Lenvatinib Treatment. (A) IHC detection of PDGFRA expression in a tissue microarray from 212 HCC cases, with the left panel showing a representative PDGFRA IHC image and the right panel illustrating the distribution of PDGFRA expression levels across various H-score ranges in 212 HCC patient specimens. (B) Kaplan-Meier survival analysis of the correlation between PDGFRA expression levels and overall survival and progression-free survival in a cohort of 212 HCC patients. (C) Schematic diagram of the treatment process for the retrospective analysis of 15 samples. (D-E) IHC staining images (D) and H-Score (E) of PDGFRA in liver cancer tissue samples from 15 patients. (F) Treatment response profiles for the 15 patients. (G) Representative magnetic resonance imaging (MRI) images of target lesions in Patients A (PDGFRA low) and Patients O (PDGFRA high) before and after treatment

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Journal of Experimental & Clinical Cancer Research

ISSN: 1756-9966

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