Fig. 6
(A) Comparison in pathologically-determined largest basal diameter and prominence of matched primary tumours of vfDNA+/UM− or UM+ samples. The black horizontal line denotes the median value for both groups. (B) Comparison in frequency of pathologically-determined breaching of Bruch’s membrane in matched primary tumours of vfDNA+/UM− or UM+ samples. (C) Correlation between concentrations of mutant vfDNA and pathologically-determined prominence of matched primary tumours in vfDNA+/UM+ samples. (D) Comparison in frequency of matched primary tumours with a poor prognostic molecular subtype (BAP1 mutation and/or monosomy 3p) of vfDNA+/UM− or UM+ samples. (E) Melanoma-related survival of patients within the vfDNA+/UM− or UM+ groups. (F) Melanoma-related survival of patients based on the inferred molecular subtypes from vfDNA measurements.