Fig. 9

Histological analyses of TRAF7 inhibition and lomustine via mediating cellular senescence and G0/G1 arrest in vivo. A The whole brain of glioma nude mice were stained HE and TRAF7 (Full scan: scale bar = 2.5 mm; higher-magnification part below: scale bar = 100 µm). B Multiplex immunofluorescence staining image of cellular senescence markers (P21 and P53) and G0/G1 arrest markers (CCND1) and Ki67 in the tumor tissue. C IHC staining the cellular senescence markers (P21 and P53) and Ki67 in tumor tissue sections (scale bar = 100 µm)