Fig. 6

Effects of IPG0521m treatment on tumor-infiltrating monocytes, macrophages and neutrophils. A UMAP projection showing subclusters of tumor-infiltrating myeloid cells. B The bubble plot showing the enrichment of distinct markers of the tumor-infiltrating myeloid cell subclusters. C Individual UMAP projection showing the proportional changes in the tumor-infiltrating myeloid cell subclusters in response to IPG0521m treatment. D Quantification of the proportional changes in the tumor-infiltrating myeloid cell subclusters in response to IPG0521m treatment. E Heat map showing the enrichment of pathways in the tumor-infiltrating myeloid cell subclusters. F The volcano maps showing changes of differentially expressed genes in the tumor-infiltrating monocytes in response to IPG0521m treatment. G UMAP projection showing the tumor-infiltrating neutrophil subclusters. H The bubble plot showing the enrichment of distinct markers and neutrophil cell-related signature genes of different neutrophil subclusters. I Individual UMAP projection showing the proportional changes in the tumor-infiltrating neutrophil subclusters in response to IPG0521m treatment. J Quantification of the proportional changes in the tumor-infiltrating neutrophil subclusters in response to IPG0521m treatment. K Heat map showing the enrichment of pathways in neutrophil subclusters. L The GO analysis showing chemokine signaling pathways in Irgm1⁺ neutrophils. M The volcano maps showing changes in the differentially expressed genes (DEGs) in Irgm1⁺ neutrophils in response to IPG0521m treatment (N) The GO analysis showing signaling pathway changes in Irgm1⁺ neutrophils in response to IPG0521m treatment. Data were shown as mean ± SD. *p < 0.05, **p < 0.01, ***p < 0.001, compared to the control