Fig. 1

Low-dose radiation therapy (LDRT) combinations with immunotherapies in metastatic melanomas. A Overview of various immunotherapies, including the most recent and clinically relevant strategies, combined with LDRT for treating metastatic melanoma. These combinations explore synergies between LDRT and immunotherapeutic approaches to enhance therapeutic efficacy. B The combination of LDRT with immunotherapies amplifies the antitumor immune response by reprogramming the tumor immune microenvironment (TIME), shifting it from immunosuppressive to immunostimulatory, thereby targeting metastatic lesions effectively