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Table 1 Cell cycle perturbations of lurbinectedin, ecubectedin and PM54 in a panel of 12 patient-derived MPM cells

From: Ecteinascidin synthetic analogues: a new class of selective inhibitors of transcription, exerting immunogenic cell death in refractory malignant pleural mesothelioma

Cell cycle phase

Untreated

Pt + PMX

lurbinectedin

ecubectedin

PM54

Sub-G1

4 ± 2

6 ± 3

22 ± 4 b

23 ± 3 b

22 ± 5 b

G0/G1

65 ± 11

69 ± 12

53 ± 12

54 ± 11

51 ± 12

S-phase

4 ± 2

6 ± 3

14 ± 4 b

18 ± 4 b

23 ± 5 b

G2/M

21 ± 5

16 ± 4

9 ± 4 a

8 ± 4 a

5 ± 3 a

  1. Values represent percentage of cells in each phase of the cell cycle
  2. ap < 0.05; bp < 0.001: vs. untreated or Pt + PMX-treated cells
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Journal of Experimental & Clinical Cancer Research

ISSN: 1756-9966

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