Table 2 Univariate and multivariate analysis of overall survival in CRC
Variables | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
HR (95% CI) | P value | HR (95% CI) | P value | |
Gender (male vs. female) | 0.86 (0.42–1.75) | 0.671 |  |  |
Age (> 60 years vs. ≤ 60 years) | 1.66 (0.79–3.50) | 0.180 |  |  |
Tumor location (Rectum vs. Colon) | 0.59 (0.29–1.20) | 0.146 |  |  |
Tumor diameter (> 5 cm vs. ≤ 5 cm) | 2.86 (1.38–5.90) | 0.005 | 1.75 (0.76–4.02) | 0.186 |
Differentiation (well / moderate vs. poor) | 0.21 (0.10–0.46) | < 0.001 | 0.28 (0.12–0.65) | 0.003 |
pT stage (T3-4 vs. T1-2) | 2.38 (0.83–6.81) | 0.107 |  |  |
pN stage (N1-2 vs. N0) | 1.74 (0.83–3.66) | 0.144 |  |  |
Distant metastasis (M1 vs. M0) | 5.88 (2.81–12.27) | < 0.001 | 3.24 (1.32–7.95) | 0.010 |
pTNM stage (III - IV vs. I - II) | 3.11 (1.27–7.62) | 0.013 | 1.70 (0.57–5.07) | 0.342 |
CEA (> 5 ng/ml vs. ≤ 5 ng/ml) | 1.22 (0.59–2.50) | 0.591 |  |  |
CA19-9 (> 27 U/ml vs. ≤ 27 U/ml) | 2.47 (1.20–5.06) | 0.014 | 1.38 (0.60–3.14) | 0.449 |
Lymphatic/microvascular/perineural invasion (Yes vs. No) | 2.59 (1.26–5.31) | 0.010 | 0.90 (0.39–2.11) | 0.810 |
Exosomal miR-106a-5p expression (High vs. Low) | 4.15 (1.78–9.68) | 0.001 | 3.28 (1.35–7.96) | 0.009 |