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Fig. 1 | Journal of Experimental & Clinical Cancer Research

Fig. 1

From: IRF2 loss is associated with reduced MHC I pathway transcripts in subsets of most human cancers and causes resistance to checkpoint immunotherapy in human and mouse melanomas

Fig. 1

A Spearman correlations between transcripts of IRF2 and those of MHC I pathway genes (β2M, Erap1/2, HLA-A, HLA-B and HLA-C, PDIA3, PSMB9-10, PSME1, TAP1/2, TAPBP and TAPBPL) in tumor tissue from patients with the indicated cancer types (TCGA abbreviations). B-D Gene expression correlation between IRF2 vs ERAP1, PSME1, PSMB9, and Casp7 transcripts in primary and/or metastatic melanomas. E Spearman correlations between IRF2 transcripts and IRF2-regulated genes (Casp7, CD274 and GSDMD) and housekeeping genes (CALR, GAPDH, PSMB-7) in tumor tissue from patients with the indicated cancer types (TCGA abbreviations). A-E Data comes from the TCGA RNAseq database and was analyzed with TIMER [35].

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Journal of Experimental & Clinical Cancer Research

ISSN: 1756-9966

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