Table 2 Clinical Trials investigating the TLR-7/9 agonists and STING agonists in human cancers

Imiquimod

(IMQ)

I, Early

7

NCT04883645; NCT03276832; NCT03196180; NCT01678352; NCT03116659; NCT03276832; NCT04279535

I

32

NCT03370406; NCT02689726; NCT01171469; NCT01264731; NCT00079300; NCT00142454; NCT02276300; NCT05055050; NCT01400672; NCT01902771; NCT03370406; NCT00788164; NCT00988559; NCT02234921; NCT01792505; NCT01795313; NCT06305910; NCT01808820; NCT01403285; NCT04808245; NCT04072900; NCT05375903; NCT00453050; NCT02600949; NCT01803152; NCT00944580; NCT03982004; NCT03872947; NCT01219348; NCT00118313; NCT05641545; NCT02454634

I/II

8

NCT01421017; NCT02224599; NCT01421017; NCT00785122; NCT03559413; NCT01191034; NCT02452307; NCT02078648

II

16

NCT03233412; NCT00899574; NCT02864147; NCT00031759; NCT01731652; NCT03180684; NCT00596336; NCT02802943; NCT00799110; NCT03534947; NCT00821964; NCT00273910; NCT00651703; NCT01909752; NCT01543464; NCT02293707

II/III

4

NCT00941252; NCT02130323; NCT01088737; NCT00384124

III

19

NCT02242929; NCT02059499; NCT02669459; NCT02329171; NCT01861535; NCT02669459; NCT01283763; NCT02394132; NCT00189280; NCT00189241; NCT00189306; NCT02059499; NCT00066872; NCT00129519; NCT01720407; NCT02242929; NCT05212246; NCT01212549; NCT02135419

IV

6

NCT01161888; NCT00314756; NCT00204555; NCT01663558; NCT00803907; NCT00581425

n.a

8

NCT02917746; NCT04859361; NCT03206138; NCT00504023; NCT00707174; NCT00463359; NCT00801320; NCT00685750

LHC165

I

1

NCT03301896

NJH395

I

1

NCT03696771

852A

I

2

NCT00095160; NCT00091689

II

3

NCT00319748; NCT00276159; NCT00189332

SHR2150

I/II

1

NCT04588324

BDB001

I

2

NCT04196530; NCT03486301

II

2

NCT03915678; NCT04819373

BDB018

I

1

NCT04840394

BDC-1001

I/II

1

NCT04278144

II

1

NCT05954143

BNT411

I/II

1

NCT04101357

DSP-0509

I/II

1

NCT03416335

RO7119929

I

1

NCT04338685

TQ-A3334

I/II

1

NCT04273815

PF-3512676 (CPG 7909)

I

1

NCT00031278

I/II

2

NCT00043420; NCT00185965

II

7

NCT00321815; NCT00043368; NCT00880581; NCT00313768; NCT00471159; NCT00070642; NCT00070629

III

2

NCT00254891; NCT00254904

SD-101

I

7

NCT02731742; NCT05607953; NCT03831295; NCT04935229; NCT01745354; NCT04050085;NCT0341090

I/II

6

NCT05220722; NCT03322384; NCT02521870; NCT02927964; NCT02254772; NCT02266147

II

1

NCT03007732

cavrotolimod (AST-008)

I/II

1

NCT03684785

CMP-001/ Vidutolimod

I

4

NCT03507699; NCT03438318; NCT03084640; NCT02680184

I/II

3

NCT03983668; NCT04387071; NCT02554812

II

8

NCT04708418; NCT04633278; NCT04698187; NCT03618641; NCT04401995; NCT04916002; NCT04807192; NCT05445609

II/III

1

NCT04695977

III

1

NCT05059522

IMO-2125/ Tilsotolimod

I

2

NCT04270864; NCT04196283

II

3

NCT03865082; NCT04126876; NCT02644967

III

1

NCT03445533

IMO-2055

I

3

NCT00633529; NCT00719199; NCT01360827

II

2

NCT01040832; NCT00729053

TAC-001

I/II

1

NCT05399654

ADU-S100/ MIW815

I

2

NCT02675439; NCT03172936

II

1

NCT03937141

MK-1454

I

1

NCT03010176

II

1

NCT04220866

MK-2118

I

1

NCT03249792

E7766

I

2

NCT04144140; NCT04109092

BMS-986301

I

1

NCT03956680

GSK3745417

I

2

NCT03843359; NCT05424380

SB 11285

I

1

NCT04096638

BI-STING/BI 1387446

I

1

NCT04147234

TAK-676

I, early

1

NCT06062602

I

1

NCT04879849

I/II

1

NCT04420884

SNX281

I

1

NCT04609579

SYNB1891

I

1

NCT04167137

IMSA101

I/II

2

NCT04020185; NCT06026254

II

2

NCT05846659; NCT05846646

DMXAA/ASA404

I

12

NCT00856336; NCT01290380; NCT00863733; NCT01299701; NCT01031212; NCT01278758; NCT00003697; NCT01299415; NCT01278849; NCT01240642; NCT01285453; NCT00674102

DMXAA/ASA404

I/II

1

NCT00832494

DMXAA/ASA404

II

3

NCT00111618; NCT01071928; NCT01057342

DMXAA/ASA404

III

2

NCT00738387; NCT00662597